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Dr. Ioannidis: We have learned a lot within a short period of time about the prevalence of the infection worldwide. There are already more than 50 studies that have presented results on how many people in different countries and locations have developed antibodies to the virus. These numbers are anywhere between 5 times (e.g. Gangelt in Germany) and 600 times (e.g. Japan) more compared to the documented cases, depending on whether a lot or limited testing was already performed in different locations. We know that the prevalence of the infection varies tremendously across countries, but also within countries, within states, and even within population groups in the same location. COVID-19 attacks some disadvantaged and deprived communities (harder), and disadvantage and deprivation means different things in different countries. Of course none of these studies are perfect, but cumulatively they provide useful composite evidence. A very crude estimate might suggest that about 150-300 million or more people have already been infected around the world, far more than the 10 million documented cases. It could even be substantially larger, if antibodies do not develop in a large share of people who get through the infection without symptoms or sparse symptoms. |
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